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The evolution of vaccine developments, from small pox to COVID-19

Thu, 2021-04-01 21:00 — mike kraft

https://www.nejm.org/doi/full/10.1056/NEJMp2034334

On the Shoulders of Giants — From Jenner’s Cowpox to mRNA Covid Vaccines

In September 2008, Katalin Karikó, Drew Weissman, and their colleagues at the University of Pennsylvania modified messenger RNA (mRNA) using nucleoside analogues. These modifications stabilized the molecule and eliminated its capacity for inducing innate immunity, thereby making mRNA a promising tool for both gene replacement and vaccination.1 In December 2020, on the basis of safety and efficacy data generated in two large, placebo-controlled studies, the Food and Drug Administration (FDA) issued emergency use authorizations for two mRNA vaccines for the prevention of Covid-19. Clearance of this hurdle by the first mRNA vaccines represents the most recent in a series of breakthroughs in the realm of viral vaccines, each building on the last and each with a compelling record of disease prevention.

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ANALYSIS: How richer countries got their vaccine supplies first

Thu, 2021-04-01 12:16 — mike kraft
See How Rich Countries Got to the Front of the Vaccine Line Many low-income nations lacked the means to preorder doses, and their residents have received just 0.1 percent of vaccine shots given worldwide. The New York Times
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Overview"Coronavirus international developments briefs

Thu, 2021-04-01 11:20 — mike kraft
Factbox-Latest on the worldwide spread of the coronavirus The World Trade Organization said risks from the uneven roll-out of coronavirus vaccination campaigns and the possible emergence of vaccine-resistant strains clouded the outlook for the global trade in goods, while raising its growth forecast slightly. Reuters Staff U.S.

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* All health workers in Italy must have coronavirus jabs, the government said, in a potentially controversial move aimed at protecting vulnerable patients and pushing back against ‘no-vax’ sentiment.

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Europe's vaccine rollout 'unacceptably slow' - WHO

Thu, 2021-04-01 11:06 — mike kraft
Covid: Europe's vaccine rollout 'unacceptably slow' - WHO The WHO says the situation in the wider Europe region is more worrying than it has been in several months. BBC News

The World Health Organization (WHO) has criticised the rollout of coronavirus vaccines in Europe as being "unacceptably slow".

It also says the situation in the region is more worrying than it has been for several months.

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EU reportly seeks 10 million AstraZenca vaccines from India

Thu, 2021-04-01 10:55 — mike kraft
Exclusive: EU seeks 10 million AstraZeneca vaccines from India to meet shortfall - Indian source The European Union has asked India to allow it to buy 10 million doses of AstraZeneca's COVID-19 vaccine from Serum Institute of India, a government official told Reuters, the latest sign of growing pressure on Delhi to export more of its production to other countries. Neha Arora U.S.
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AstraZeneca vaccine: Status report on which countries are using and which ones are suspending

Thu, 2021-04-01 10:42 — mike kraft
Factbox: Some countries limit AstraZeneca vaccine use amid concern over rare blood clots Some countries are restricting use of the AstraZeneca vaccine against COVID-19 while others have resumed inoculations, as investigations into reports of rare, and sometimes severe, blood clots continue. Reuters Staff U.S.
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Indications that Vaccines Help Some COVID Long-Haulers

Thu, 2021-04-01 10:33 — mike kraft

An estimated 10% to 30% of people who get COVID-19 suffer from lingering symptoms of the disease, or what's known as "long COVID."

Judy Dodd, who lives in New York City, is one of them. She spent nearly a year plagued by headaches, shortness of breath, extreme fatigue and problems with smell, among other symptoms.

She says she worried that this "slog through life" was going to be her new normal.

Everything changed after she got her COVID-19 vaccine.

"I was like a new person, it was the craziest thing ever," says Dodd, referring to how many of her health problems subsided significantly after her second shot.

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Early trials begin of Moderna vaccine against South African variant

Thu, 2021-04-01 10:06 — mike kraft
NIH begins early trials of Moderna vaccine against South African The National Institutes of Health has begun early-stage clinical trials of an investigational coronavirus vaccine from Moderna intended to protect against a strain of the virus first discovered in Nathaniel Weixel TheHill
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Pfizer says tests show its vaccine is effective against the South African variant

Thu, 2021-04-01 09:37 — mike kraft
Pfizer says vaccine protection lasts at least 6 months after 2nd shot "It is an important step to further confirm the strong efficacy and good safety data we have seen so far," BioNTech CEO Ugur Sahin said. NBC News
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Covid-19 vaccine doses are delayed by a mix-up in U.S. factory

Wed, 2021-03-31 18:44 — mike kraft

Workers at a Baltimore plant manufacturing two coronavirus vaccines accidentally conflated the vaccines’ ingredients several weeks ago, ruining about 15 million doses of Johnson & Johnson’s vaccine and forcing regulators to delay authorization of the plant’s production lines.

The plant is run by Emergent BioSolutions, a manufacturing partner to both Johnson & Johnson and AstraZeneca. Federal officials attributed the mistake to human error.

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